Acquired alpha 1-antitrypsin deficiency in tropical pulmonary eosinophilia
Identifieur interne : 005111 ( Main/Exploration ); précédent : 005110; suivant : 005112Acquired alpha 1-antitrypsin deficiency in tropical pulmonary eosinophilia
Auteurs : Debidas Ray ; S. Harikrishna ; Chandra Immanuel ; Lalitha Victor ; Sudha Subramanyam ; V. KumaraswamiSource :
- The Indian Journal of Medical Research [ 0971-5916 ] ; 2011.
Descripteurs français
- KwdFr :
- Adulte, Allèles, Animaux, Diéthylcarbamazine (usage thérapeutique), Déficit en alpha-1-antitrypsine (génétique), Déficit en alpha-1-antitrypsine (sang), Déficit en alpha-1-antitrypsine (étiologie), Femelle, Filariose lymphatique (épidémiologie), Filarioses (épidémiologie), Humains, Mâle, Poumon éosinophile (), Stress oxydatif, Sujet âgé, Wuchereria bancrofti (isolement et purification), alpha-1-Antitrypsine (génétique), alpha-1-Antitrypsine (sang), Études cas-témoins.
- MESH :
- génétique : Déficit en alpha-1-antitrypsine, alpha-1-Antitrypsine.
- isolement et purification : Wuchereria bancrofti.
- sang : Déficit en alpha-1-antitrypsine, alpha-1-Antitrypsine.
- usage thérapeutique : Diéthylcarbamazine.
- épidémiologie : Filariose lymphatique, Filarioses.
- étiologie : Déficit en alpha-1-antitrypsine.
- Adulte, Allèles, Animaux, Femelle, Humains, Mâle, Poumon éosinophile, Stress oxydatif, Sujet âgé, Études cas-témoins.
English descriptors
- KwdEn :
- Adult, Aged, Alleles, Animals, Case-Control Studies, Diethylcarbamazine (therapeutic use), Elephantiasis, Filarial (epidemiology), Female, Filariasis (epidemiology), Humans, Male, Oxidative Stress, Pulmonary Eosinophilia (complications), Wuchereria bancrofti (isolation & purification), alpha 1-Antitrypsin (blood), alpha 1-Antitrypsin (genetics), alpha 1-Antitrypsin Deficiency (blood), alpha 1-Antitrypsin Deficiency (etiology), alpha 1-Antitrypsin Deficiency (genetics).
- MESH :
- chemical , blood : alpha 1-Antitrypsin.
- chemical , genetics : alpha 1-Antitrypsin.
- chemical , therapeutic use : Diethylcarbamazine.
- blood : alpha 1-Antitrypsin Deficiency.
- complications : Pulmonary Eosinophilia.
- epidemiology : Elephantiasis, Filarial, Filariasis.
- etiology : alpha 1-Antitrypsin Deficiency.
- genetics : alpha 1-Antitrypsin Deficiency.
- isolation & purification : Wuchereria bancrofti.
- Adult, Aged, Alleles, Animals, Case-Control Studies, Female, Humans, Male, Oxidative Stress.
Abstract
Observation of an increased frequency of an intermediate deficiency of serum alpha1-antitrypsin (α1-AT) in patients with Tropical Pulmonary Eosinophilia (TPE) was earlier reported. Though the possibility of existence of an acquired deficiency was suggested, without phenotyping a hereditary α1-AT deficiency in TPE could not totally be ruled out. In this study, we have done Pi (Protease inhibitor) phenotyping to investigate the possibility of association of any heterozygous (or homozygous) α1-AT deficiency in patients with TPE.
Serum a1antitrypsin (α1-AT) was measured in 103 patients (Group A) with TPE, 99 patients with pulmonary eosinophilia who had associated intestinal worm infestation (Group B) and 43 healthy volunteers who served as controls. In 19 α1-AT deficient patients (9 of Group A and 10 of Group B), α1-AT level was measured before and after treatment. In 58 patients with TPE and in 5 controls, phenotyping was done.
Fifteen patients of Group A and 16 from Group B showed intermediate α1-AT deficiency (150 mg % or less. None of the control subjects had α1-AT deficiency (<200 mg%). After treatment with DEC and/or deworming, in 19 patients there was a significant (
The observed α1-AT deficiency may be due to the chronic inflammation in TPE and associated oxidative stress. However, in such α1-AT deficient patients with TPE and those with worm infested pulmonary eosinophilia, faecal α1-AT concentration and faecal α1-AT clearance should be routinely estimated to rule out the possibility of any intestinal protein loss.
Url:
PubMed: 21808138
PubMed Central: 3171921
Affiliations:
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Le document en format XML
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Harikrishna</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Immanuel, Chandra" sort="Immanuel, Chandra" uniqKey="Immanuel C" first="Chandra" last="Immanuel">Chandra Immanuel</name><affiliation><nlm:aff id="aff2"><italic>Department of Biochemistry, Tuberculosis Research Centre (ICMR), Chennai, India</italic></nlm:aff></affiliation></author><author><name sortKey="Victor, Lalitha" sort="Victor, Lalitha" uniqKey="Victor L" first="Lalitha" last="Victor">Lalitha Victor</name><affiliation><nlm:aff id="aff2"><italic>Department of Biochemistry, Tuberculosis Research Centre (ICMR), Chennai, India</italic></nlm:aff></affiliation></author><author><name sortKey="Subramanyam, Sudha" sort="Subramanyam, Sudha" uniqKey="Subramanyam S" first="Sudha" last="Subramanyam">Sudha Subramanyam</name><affiliation><nlm:aff id="aff3"><italic>Department of Pathology, Tuberculosis Research Centre (ICMR), Chennai, India</italic></nlm:aff></affiliation></author><author><name sortKey="Kumaraswami, V" sort="Kumaraswami, V" uniqKey="Kumaraswami V" first="V." last="Kumaraswami">V. Kumaraswami</name><affiliation><nlm:aff id="aff4"><italic>Department of Immunology, Tuberculosis Research Centre (ICMR), Chennai, India</italic></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">21808138</idno><idno type="pmc">3171921</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3171921</idno><idno type="RBID">PMC:3171921</idno><date when="2011">2011</date><idno type="wicri:Area/Pmc/Corpus">003F18</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">003F18</idno><idno type="wicri:Area/Pmc/Curation">003F17</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">003F17</idno><idno type="wicri:Area/Pmc/Checkpoint">003115</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">003115</idno><idno type="wicri:source">PubMed</idno><idno type="wicri:Area/PubMed/Corpus">002503</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002503</idno><idno type="wicri:Area/PubMed/Curation">002503</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002503</idno><idno type="wicri:Area/PubMed/Checkpoint">002503</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">002503</idno><idno type="wicri:Area/Ncbi/Merge">004572</idno><idno type="wicri:Area/Ncbi/Curation">004572</idno><idno type="wicri:Area/Ncbi/Checkpoint">004572</idno><idno type="wicri:doubleKey">0971-5916:2011:Ray D:acquired:alpha:antitrypsin</idno><idno type="wicri:Area/Main/Merge">005150</idno><idno type="wicri:Area/Main/Curation">005111</idno><idno type="wicri:Area/Main/Exploration">005111</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Acquired alpha 1-antitrypsin deficiency in tropical pulmonary eosinophilia</title><author><name sortKey="Ray, Debidas" sort="Ray, Debidas" uniqKey="Ray D" first="Debidas" last="Ray">Debidas Ray</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Harikrishna, S" sort="Harikrishna, S" uniqKey="Harikrishna S" first="S." last="Harikrishna">S. Harikrishna</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Immanuel, Chandra" sort="Immanuel, Chandra" uniqKey="Immanuel C" first="Chandra" last="Immanuel">Chandra Immanuel</name><affiliation><nlm:aff id="aff2"><italic>Department of Biochemistry, Tuberculosis Research Centre (ICMR), Chennai, India</italic></nlm:aff></affiliation></author><author><name sortKey="Victor, Lalitha" sort="Victor, Lalitha" uniqKey="Victor L" first="Lalitha" last="Victor">Lalitha Victor</name><affiliation><nlm:aff id="aff2"><italic>Department of Biochemistry, Tuberculosis Research Centre (ICMR), Chennai, India</italic></nlm:aff></affiliation></author><author><name sortKey="Subramanyam, Sudha" sort="Subramanyam, Sudha" uniqKey="Subramanyam S" first="Sudha" last="Subramanyam">Sudha Subramanyam</name><affiliation><nlm:aff id="aff3"><italic>Department of Pathology, Tuberculosis Research Centre (ICMR), Chennai, India</italic></nlm:aff></affiliation></author><author><name sortKey="Kumaraswami, V" sort="Kumaraswami, V" uniqKey="Kumaraswami V" first="V." last="Kumaraswami">V. Kumaraswami</name><affiliation><nlm:aff id="aff4"><italic>Department of Immunology, Tuberculosis Research Centre (ICMR), Chennai, India</italic></nlm:aff></affiliation></author></analytic><series><title level="j">The Indian Journal of Medical Research</title><idno type="ISSN">0971-5916</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Alleles</term><term>Animals</term><term>Case-Control Studies</term><term>Diethylcarbamazine (therapeutic use)</term><term>Elephantiasis, Filarial (epidemiology)</term><term>Female</term><term>Filariasis (epidemiology)</term><term>Humans</term><term>Male</term><term>Oxidative Stress</term><term>Pulmonary Eosinophilia (complications)</term><term>Wuchereria bancrofti (isolation & purification)</term><term>alpha 1-Antitrypsin (blood)</term><term>alpha 1-Antitrypsin (genetics)</term><term>alpha 1-Antitrypsin Deficiency (blood)</term><term>alpha 1-Antitrypsin Deficiency (etiology)</term><term>alpha 1-Antitrypsin Deficiency (genetics)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Allèles</term><term>Animaux</term><term>Diéthylcarbamazine (usage thérapeutique)</term><term>Déficit en alpha-1-antitrypsine (génétique)</term><term>Déficit en alpha-1-antitrypsine (sang)</term><term>Déficit en alpha-1-antitrypsine (étiologie)</term><term>Femelle</term><term>Filariose lymphatique (épidémiologie)</term><term>Filarioses (épidémiologie)</term><term>Humains</term><term>Mâle</term><term>Poumon éosinophile ()</term><term>Stress oxydatif</term><term>Sujet âgé</term><term>Wuchereria bancrofti (isolement et purification)</term><term>alpha-1-Antitrypsine (génétique)</term><term>alpha-1-Antitrypsine (sang)</term><term>Études cas-témoins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>alpha 1-Antitrypsin</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>alpha 1-Antitrypsin</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Diethylcarbamazine</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>alpha 1-Antitrypsin Deficiency</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Pulmonary Eosinophilia</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Elephantiasis, Filarial</term><term>Filariasis</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>alpha 1-Antitrypsin Deficiency</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>alpha 1-Antitrypsin Deficiency</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Déficit en alpha-1-antitrypsine</term><term>alpha-1-Antitrypsine</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Wuchereria bancrofti</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Wuchereria bancrofti</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Déficit en alpha-1-antitrypsine</term><term>alpha-1-Antitrypsine</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Diéthylcarbamazine</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Filariose lymphatique</term><term>Filarioses</term></keywords><keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Déficit en alpha-1-antitrypsine</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Alleles</term><term>Animals</term><term>Case-Control Studies</term><term>Female</term><term>Humans</term><term>Male</term><term>Oxidative Stress</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Allèles</term><term>Animaux</term><term>Femelle</term><term>Humains</term><term>Mâle</term><term>Poumon éosinophile</term><term>Stress oxydatif</term><term>Sujet âgé</term><term>Études cas-témoins</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="st1"><title>Background & objectives:</title><p>Observation of an increased frequency of an intermediate deficiency of serum alpha1-antitrypsin (α1-AT) in patients with Tropical Pulmonary Eosinophilia (TPE) was earlier reported. Though the possibility of existence of an acquired deficiency was suggested, without phenotyping a hereditary α1-AT deficiency in TPE could not totally be ruled out. In this study, we have done Pi (Protease inhibitor) phenotyping to investigate the possibility of association of any heterozygous (or homozygous) α1-AT deficiency in patients with TPE.</p></sec><sec id="st2"><title>Methods:</title><p>Serum a1antitrypsin (α1-AT) was measured in 103 patients (Group A) with TPE, 99 patients with pulmonary eosinophilia who had associated intestinal worm infestation (Group B) and 43 healthy volunteers who served as controls. In 19 α1-AT deficient patients (9 of Group A and 10 of Group B), α1-AT level was measured before and after treatment. In 58 patients with TPE and in 5 controls, phenotyping was done.</p></sec><sec id="st3"><title>Results:</title><p>Fifteen patients of Group A and 16 from Group B showed intermediate α1-AT deficiency (150 mg % or less. None of the control subjects had α1-AT deficiency (<200 mg%). After treatment with DEC and/or deworming, in 19 patients there was a significant (<italic>P</italic> < 0.001) rise in α1-AT levels. Results of phenotyping showed that all had M<sub>1</sub> or M<sub>2</sub> allele and none had S or Z variant (either homozygous or heterozygous) thus ruling out any underlying genetic cause for the observed α1-AT deficiency.</p></sec><sec id="st4"><title>Interpretation & conclusions:</title><p>The observed α1-AT deficiency may be due to the chronic inflammation in TPE and associated oxidative stress. However, in such α1-AT deficient patients with TPE and those with worm infested pulmonary eosinophilia, faecal α1-AT concentration and faecal α1-AT clearance should be routinely estimated to rule out the possibility of any intestinal protein loss.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Ray, D" uniqKey="Ray D">D Ray</name></author><author><name sortKey="Sri Krishna, K" uniqKey="Sri Krishna K">K Sri Krishna</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rom, Wn" uniqKey="Rom W">WN Rom</name></author><author><name sortKey="Vijayan, Vk" uniqKey="Vijayan V">VK Vijayan</name></author><author><name sortKey="Cornelius, Mj" uniqKey="Cornelius M">MJ Cornelius</name></author><author><name sortKey="Kumaraswami, V" uniqKey="Kumaraswami V">V Kumaraswami</name></author><author><name sortKey="Prabhakar, R" uniqKey="Prabhakar R">R Prabhakar</name></author><author><name sortKey="Ottesen, Ea" uniqKey="Ottesen E">EA Ottesen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mancini, G" uniqKey="Mancini G">G Mancini</name></author><author><name sortKey="Carbonara, Ao" uniqKey="Carbonara A">AO Carbonara</name></author><author><name sortKey="Heremans, Jf" uniqKey="Heremans J">JF Heremans</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gadek, Ge" uniqKey="Gadek G">GE Gadek</name></author><author><name sortKey="Crystal, Rg" uniqKey="Crystal R">RG Crystal</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mulgrew, At" uniqKey="Mulgrew A">AT Mulgrew</name></author><author><name sortKey="Taggart, Cc" uniqKey="Taggart C">CC Taggart</name></author><author><name sortKey="Mcelvaney, Ng" uniqKey="Mcelvaney N">NG McElvaney</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Macnee, W" uniqKey="Macnee W">W MacNee</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sayyed, Ak" uniqKey="Sayyed A">AK Sayyed</name></author><author><name sortKey="Deshpande, Kh" uniqKey="Deshpande K">KH Deshpande</name></author><author><name sortKey="Suryakar, An" uniqKey="Suryakar A">AN Suryakar</name></author><author><name sortKey="Ankush, Rd" uniqKey="Ankush R">RD Ankush</name></author><author><name sortKey="Katkam, Rv" uniqKey="Katkam R">RV Katkam</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Buhl, R" uniqKey="Buhl R">R Buhl</name></author><author><name sortKey="Meyer, A" uniqKey="Meyer A">A Meyer</name></author><author><name sortKey="Vogelmeier, C" uniqKey="Vogelmeier C">C Vogelmeier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pal, Bk" uniqKey="Pal B">BK Pal</name></author><author><name sortKey="Kulkarni, S" uniqKey="Kulkarni S">S Kulkarni</name></author><author><name sortKey="Bhandari, Y" uniqKey="Bhandari Y">Y Bhandari</name></author><author><name sortKey="Ganesh, Bb" uniqKey="Ganesh B">BB Ganesh</name></author><author><name sortKey="Goswami, K" uniqKey="Goswami K">K Goswami</name></author><author><name sortKey="Reddy, Mv" uniqKey="Reddy M">MV Reddy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rocha, A" uniqKey="Rocha A">A Rocha</name></author><author><name sortKey="Dreyer, G" uniqKey="Dreyer G">G Dreyer</name></author><author><name sortKey="Poindexter, Rw" uniqKey="Poindexter R">RW Poindexter</name></author><author><name sortKey="Ottesen, Ea" uniqKey="Ottesen E">EA Ottesen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vijayan, Vk" uniqKey="Vijayan V">VK Vijayan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sullivan, Pb" uniqKey="Sullivan P">PB Sullivan</name></author><author><name sortKey="Lunn, Pg" uniqKey="Lunn P">PG Lunn</name></author><author><name sortKey="Northrop Clewes, Ca" uniqKey="Northrop Clewes C">CA Northrop-Clewes</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gupta, Mc" uniqKey="Gupta M">MC Gupta</name></author><author><name sortKey="Basu, Ak" uniqKey="Basu A">AK Basu</name></author><author><name sortKey="Tandon, Bn" uniqKey="Tandon B">BN Tandon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Korman, Sh" uniqKey="Korman S">SH Korman</name></author><author><name sortKey="Bar Oz, B" uniqKey="Bar Oz B">B Bar OZ</name></author><author><name sortKey="Mandleberg, A" uniqKey="Mandleberg A">A Mandleberg</name></author><author><name sortKey="Matoth, I" uniqKey="Matoth I">I Matoth</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list></list><tree><noCountry><name sortKey="Harikrishna, S" sort="Harikrishna, S" uniqKey="Harikrishna S" first="S." last="Harikrishna">S. Harikrishna</name><name sortKey="Immanuel, Chandra" sort="Immanuel, Chandra" uniqKey="Immanuel C" first="Chandra" last="Immanuel">Chandra Immanuel</name><name sortKey="Kumaraswami, V" sort="Kumaraswami, V" uniqKey="Kumaraswami V" first="V." last="Kumaraswami">V. Kumaraswami</name><name sortKey="Ray, Debidas" sort="Ray, Debidas" uniqKey="Ray D" first="Debidas" last="Ray">Debidas Ray</name><name sortKey="Subramanyam, Sudha" sort="Subramanyam, Sudha" uniqKey="Subramanyam S" first="Sudha" last="Subramanyam">Sudha Subramanyam</name><name sortKey="Victor, Lalitha" sort="Victor, Lalitha" uniqKey="Victor L" first="Lalitha" last="Victor">Lalitha Victor</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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